Carlos Alonso-Ron

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Публикации

Participation of HERG channel cytoplasmic structures on regulation by the G protein-coupled TRH receptor.

Alonso-Ron C, Barros F, Manso DG, Gómez-Varela D, Miranda P, Carretero L, Domínguez P, de la Peña P.
Human ether-a-go-go-related gene (HERG) channels heterologously expressed in Xenopus oocytes are regulated by the activation of G protein-coupled hormone receptors that, like the thyrotropin-releasing hormone (TRH) receptor, activate phospholipase C. Previous work with serially deleted HERG...
→ HERG . Potassium channel . Gating . Hormonal regulation . Cytoplasmic domains . Amino terminus . S4–S5 linker  

FRET with multiply labeled HERG K(+) channels as a reporter of the in vivo coarse architecture of the cytoplasmic domains.

Miranda P, Manso DG, Barros F, Carretero L, Hughes TE, Alonso-Ron C, Domínguez P, de la Peña P.
The intracellular N-terminus of human ether-a-go-go-related gene (HERG) potassium channels constitutes a key determinant of activation and deactivation characteristics and is necessary for hormone-induced modifications of gating properties. However, the general organization of the long amino and...
→ HERG Potassium channel Cytoplasmic domain architecture FRET  

Thermodynamic and kinetic properties of amino-terminal and S4-S5 loop HERG channel mutants under steady-state conditions.

Alonso-Ron C, de la Peña P, Miranda P, Domínguez P, Barros F.
Gating kinetics and underlying thermodynamic properties of human ether-a-go-go-related gene (HERG) K(+) channels expressed in Xenopus oocytes were studied using protocols able to yield true steady-state kinetic parameters. Channel mutants lacking the initial 16 residues of the amino terminus...
→ hERG   → thermodynamics   → kinectics   → gating  
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